Scores
Each row corresponds to a position in the reference protein.  Below each position is the fraction of sequences that contain one of the basic amino acids.  A low fraction indicates the position is either severely gapped or unalignable and has little information.  Expect poor prediction at these positions.
Each column corresponds to one of the twenty amino acids. 
Each entry contains the score at a particular position (row) for an amino acid substitution (column).  Substitutions predicted to be intolerant are highlighted in red.
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 1M 0.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 2K 0.21 | 0.75 | 0.08 | 0.57 | 0.58 | 0.07 | 0.65 | 0.15 | 0.12 | 1.00 | 0.21 | 0.08 | 0.58 | 0.27 | 0.39 | 0.47 | 0.84 | 0.45 | 0.21 | 0.03 | 0.09 | 
|---|
|
| 3P 0.21 | 0.39 | 0.05 | 0.41 | 0.45 | 0.08 | 0.37 | 0.19 | 0.11 | 0.99 | 0.21 | 0.07 | 0.60 | 1.00 | 0.42 | 0.98 | 0.44 | 0.36 | 0.16 | 0.04 | 0.13 | 
|---|
|
| 4V 0.61 | 0.13 | 0.03 | 0.01 | 0.02 | 0.03 | 0.01 | 0.00 | 0.59 | 0.02 | 0.17 | 0.04 | 0.01 | 0.17 | 0.01 | 0.01 | 0.02 | 0.09 | 1.00 | 0.00 | 0.01 | 
|---|
|
| 5T 0.93 | 0.03 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.02 | 0.01 | 0.01 | 0.11 | 0.18 | 1.00 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 6L 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 1.00 | 0.00 | 0.72 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.00 | 0.00 | 
|---|
|
| 7Y 1.00 | 0.28 | 0.04 | 0.13 | 0.34 | 0.12 | 0.17 | 0.19 | 0.12 | 1.00 | 0.24 | 0.08 | 0.21 | 0.15 | 0.39 | 0.82 | 0.24 | 0.25 | 0.16 | 0.04 | 0.20 | 
|---|
|
| 8D 1.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 9V 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 10A 1.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 11E 1.00 | 0.26 | 0.02 | 0.12 | 0.43 | 0.03 | 0.10 | 0.10 | 0.13 | 0.74 | 0.16 | 0.03 | 0.12 | 0.08 | 0.19 | 1.00 | 0.16 | 0.14 | 0.08 | 0.01 | 0.04 | 
|---|
|
| 12Y 1.00 | 0.60 | 0.18 | 0.29 | 0.45 | 0.70 | 0.37 | 0.55 | 0.41 | 0.43 | 0.70 | 0.23 | 0.37 | 0.24 | 0.38 | 0.43 | 0.49 | 0.46 | 0.53 | 0.18 | 1.00 | 
|---|
|
| 13A 1.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 14G 1.00 | 0.02 | 0.00 | 0.08 | 0.03 | 0.00 | 1.00 | 0.02 | 0.00 | 0.16 | 0.01 | 0.00 | 0.34 | 0.02 | 0.02 | 0.07 | 0.08 | 0.02 | 0.01 | 0.00 | 0.01 | 
|---|
|
| 15V 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 16S 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 17Y 1.00 | 0.48 | 0.17 | 0.19 | 0.30 | 0.66 | 0.31 | 0.53 | 0.44 | 0.27 | 0.63 | 0.33 | 0.29 | 0.19 | 0.28 | 0.35 | 0.40 | 0.37 | 0.52 | 0.17 | 1.00 | 
|---|
|
| 18Q 1.00 | 1.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.18 | 0.01 | 0.12 | 0.12 | 0.02 | 0.00 | 0.00 | 
|---|
|
| 19T 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 20V 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 21S 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 22R 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 23V 1.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 24V 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.29 | 0.00 | 0.91 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.01 | 
|---|
|
| 25N 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 26Q 1.00 | 0.28 | 0.04 | 0.80 | 0.47 | 0.06 | 1.00 | 0.20 | 0.07 | 0.41 | 0.12 | 0.04 | 0.82 | 0.15 | 0.42 | 0.20 | 0.42 | 0.24 | 0.10 | 0.02 | 0.17 | 
|---|
|
| 27A 1.00 | 0.91 | 0.08 | 0.79 | 0.96 | 0.17 | 0.40 | 0.21 | 0.27 | 1.00 | 0.39 | 0.13 | 0.79 | 0.29 | 0.58 | 0.54 | 0.90 | 0.60 | 0.40 | 0.05 | 0.25 | 
|---|
|
| 28S 1.00 | 0.61 | 0.04 | 0.50 | 0.87 | 0.03 | 0.26 | 0.08 | 0.13 | 0.69 | 0.28 | 0.07 | 0.50 | 1.00 | 0.47 | 0.46 | 0.79 | 0.57 | 0.20 | 0.01 | 0.03 | 
|---|
|
| 29H 1.00 | 0.51 | 0.16 | 0.23 | 0.32 | 0.64 | 0.50 | 0.73 | 0.37 | 0.39 | 0.67 | 0.21 | 1.00 | 0.20 | 0.31 | 0.35 | 0.62 | 0.47 | 0.53 | 0.17 | 1.00 | 
|---|
|
| 30V 1.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 31S 1.00 | 0.63 | 0.04 | 0.49 | 0.69 | 0.03 | 0.31 | 0.09 | 0.13 | 1.00 | 0.21 | 0.07 | 0.38 | 0.19 | 0.41 | 0.40 | 0.81 | 0.49 | 0.20 | 0.01 | 0.03 | 
|---|
|
| 32A 1.00 | 0.61 | 0.04 | 0.51 | 1.00 | 0.03 | 0.30 | 0.06 | 0.06 | 0.33 | 0.11 | 0.04 | 0.17 | 0.24 | 0.30 | 0.16 | 0.34 | 0.20 | 0.12 | 0.01 | 0.04 | 
|---|
|
| 33K 1.00 | 0.76 | 0.04 | 0.60 | 1.00 | 0.04 | 0.31 | 0.13 | 0.15 | 0.89 | 0.25 | 0.09 | 0.45 | 0.22 | 0.48 | 0.43 | 0.62 | 0.53 | 0.25 | 0.01 | 0.03 | 
|---|
|
| 34T 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.08 | 1.00 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 35R 1.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.01 | 0.00 | 0.01 | 0.00 | 0.07 | 1.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 36E 1.00 | 0.30 | 0.02 | 0.53 | 1.00 | 0.03 | 0.14 | 0.14 | 0.06 | 0.62 | 0.17 | 0.04 | 0.18 | 0.14 | 0.46 | 0.19 | 0.25 | 0.20 | 0.10 | 0.01 | 0.03 | 
|---|
|
| 37K 1.00 | 0.31 | 0.01 | 0.10 | 0.20 | 0.02 | 0.09 | 0.05 | 0.05 | 1.00 | 0.15 | 0.03 | 0.11 | 0.07 | 0.17 | 0.55 | 0.22 | 0.13 | 0.12 | 0.01 | 0.03 | 
|---|
|
| 38V 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 39E 1.00 | 0.47 | 0.13 | 0.22 | 0.44 | 0.52 | 0.29 | 0.43 | 0.41 | 0.42 | 1.00 | 0.25 | 0.31 | 0.19 | 0.31 | 0.42 | 0.38 | 0.36 | 0.42 | 0.14 | 0.71 | 
|---|
|
| 40A 1.00 | 0.70 | 0.03 | 0.54 | 1.00 | 0.03 | 0.24 | 0.08 | 0.12 | 0.67 | 0.19 | 0.07 | 0.35 | 0.17 | 0.41 | 0.38 | 0.50 | 0.46 | 0.18 | 0.01 | 0.02 | 
|---|
|
| 41A 1.00 | 0.95 | 0.06 | 0.02 | 0.05 | 0.04 | 0.00 | 0.01 | 0.56 | 0.05 | 0.31 | 0.07 | 0.02 | 0.07 | 0.04 | 0.03 | 0.05 | 0.31 | 1.00 | 0.01 | 0.01 | 
|---|
|
| 42M 1.00 | 0.44 | 0.02 | 0.01 | 0.02 | 0.07 | 0.01 | 0.01 | 1.00 | 0.02 | 0.56 | 0.35 | 0.01 | 0.02 | 0.02 | 0.01 | 0.02 | 0.07 | 0.42 | 0.01 | 0.01 | 
|---|
|
| 43A 1.00 | 0.68 | 0.03 | 0.60 | 1.00 | 0.02 | 0.19 | 0.06 | 0.09 | 0.60 | 0.15 | 0.05 | 0.28 | 0.14 | 0.29 | 0.35 | 0.41 | 0.28 | 0.14 | 0.01 | 0.02 | 
|---|
|
| 44E 1.00 | 0.34 | 0.03 | 0.27 | 1.00 | 0.03 | 0.18 | 0.09 | 0.09 | 0.92 | 0.16 | 0.06 | 0.24 | 0.14 | 0.51 | 0.80 | 0.39 | 0.27 | 0.30 | 0.01 | 0.04 | 
|---|
|
| 45L 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.07 | 0.00 | 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.00 | 0.00 | 
|---|
|
| 46N 1.00 | 0.28 | 0.02 | 0.64 | 0.26 | 0.02 | 1.00 | 0.15 | 0.02 | 0.14 | 0.03 | 0.01 | 0.90 | 0.07 | 0.10 | 0.08 | 0.29 | 0.10 | 0.03 | 0.01 | 0.04 | 
|---|
|
| 47Y 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 
|---|
|
| 48I 0.89 | 0.70 | 0.19 | 0.35 | 0.50 | 0.71 | 0.41 | 0.60 | 0.49 | 0.54 | 0.71 | 0.24 | 0.42 | 0.27 | 0.48 | 0.60 | 0.57 | 0.56 | 0.56 | 0.19 | 1.00 | 
|---|
|
| 49P 0.89 | 0.05 | 0.02 | 0.02 | 0.03 | 0.06 | 0.03 | 0.04 | 0.03 | 0.14 | 0.05 | 0.02 | 0.03 | 1.00 | 0.03 | 0.03 | 0.04 | 0.10 | 0.04 | 0.02 | 0.08 | 
|---|
|
| 50N 0.89 | 0.21 | 0.08 | 0.09 | 0.12 | 0.28 | 0.14 | 0.22 | 0.16 | 0.12 | 0.26 | 0.09 | 1.00 | 0.09 | 0.12 | 0.26 | 0.23 | 0.16 | 0.26 | 0.08 | 0.45 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 51R 0.96 | 0.93 | 0.20 | 0.47 | 0.74 | 0.70 | 0.49 | 0.58 | 0.47 | 0.70 | 0.76 | 0.26 | 0.52 | 0.32 | 0.56 | 0.63 | 0.71 | 0.63 | 0.63 | 0.19 | 1.00 | 
|---|
|
| 52V 1.00 | 0.79 | 0.07 | 0.61 | 0.97 | 0.08 | 0.39 | 0.15 | 0.21 | 1.00 | 0.33 | 0.12 | 0.53 | 0.29 | 0.60 | 0.62 | 0.83 | 0.73 | 0.38 | 0.03 | 0.08 | 
|---|
|
| 53A 1.00 | 1.00 | 0.02 | 0.02 | 0.03 | 0.01 | 0.04 | 0.01 | 0.11 | 0.09 | 0.05 | 0.02 | 0.02 | 0.16 | 0.02 | 0.02 | 0.11 | 0.06 | 0.17 | 0.00 | 0.01 | 
|---|
|
| 54Q 1.00 | 0.14 | 0.01 | 0.03 | 0.09 | 0.01 | 0.04 | 0.04 | 0.02 | 0.43 | 0.05 | 0.02 | 0.12 | 0.04 | 0.49 | 1.00 | 0.06 | 0.06 | 0.13 | 0.01 | 0.02 | 
|---|
|
| 55Q 1.00 | 0.90 | 0.05 | 0.62 | 0.99 | 0.05 | 0.88 | 0.12 | 0.19 | 1.00 | 0.30 | 0.11 | 0.55 | 0.27 | 0.84 | 0.68 | 0.84 | 0.57 | 0.35 | 0.02 | 0.04 | 
|---|
|
| 56L 1.00 | 0.17 | 0.01 | 0.02 | 0.02 | 0.02 | 0.06 | 0.01 | 0.04 | 0.03 | 1.00 | 0.03 | 0.02 | 0.03 | 0.07 | 0.02 | 0.17 | 0.05 | 0.05 | 0.00 | 0.01 | 
|---|
|
| 57A 1.00 | 1.00 | 0.02 | 0.04 | 0.11 | 0.02 | 0.09 | 0.05 | 0.06 | 0.51 | 0.08 | 0.03 | 0.07 | 0.13 | 0.13 | 0.42 | 0.11 | 0.10 | 0.22 | 0.01 | 0.03 | 
|---|
|
| 58G 1.00 | 0.76 | 0.06 | 0.62 | 1.00 | 0.08 | 0.45 | 0.14 | 0.20 | 0.95 | 0.34 | 0.14 | 0.50 | 0.28 | 0.69 | 0.55 | 0.87 | 0.64 | 0.34 | 0.02 | 0.08 | 
|---|
|
| 59K 1.00 | 0.03 | 0.00 | 0.02 | 0.13 | 0.00 | 0.02 | 0.02 | 0.01 | 1.00 | 0.02 | 0.01 | 0.12 | 0.02 | 0.42 | 0.47 | 0.03 | 0.12 | 0.02 | 0.00 | 0.01 | 
|---|
|
| 60Q 1.00 | 0.54 | 0.03 | 0.36 | 0.58 | 0.03 | 0.22 | 0.07 | 0.11 | 0.95 | 0.18 | 0.06 | 0.37 | 0.16 | 0.89 | 1.00 | 0.68 | 0.54 | 0.25 | 0.01 | 0.02 | 
|---|
|
| 61S 1.00 | 0.26 | 0.01 | 0.10 | 0.20 | 0.02 | 0.06 | 0.11 | 0.04 | 0.14 | 0.06 | 0.02 | 0.08 | 0.05 | 0.16 | 0.08 | 0.55 | 1.00 | 0.22 | 0.01 | 0.02 | 
|---|
|
| 62L 0.96 | 0.89 | 0.13 | 0.64 | 1.00 | 0.37 | 0.49 | 0.36 | 0.34 | 0.94 | 0.57 | 0.19 | 0.57 | 0.33 | 0.65 | 0.61 | 0.82 | 0.69 | 0.48 | 0.10 | 0.49 | 
|---|
|
| 63L 0.96 | 0.51 | 0.18 | 0.21 | 0.28 | 0.70 | 0.33 | 0.54 | 0.42 | 0.30 | 0.73 | 0.22 | 0.31 | 0.21 | 0.30 | 0.35 | 0.40 | 0.52 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 64I 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.99 | 0.00 | 0.13 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 65G 1.00 | 0.18 | 0.01 | 0.01 | 0.01 | 0.00 | 1.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.11 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 66V 1.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.05 | 0.01 | 0.00 | 0.42 | 0.01 | 0.62 | 0.12 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 1.00 | 0.13 | 0.01 | 
|---|
|
| 67A 1.00 | 0.34 | 0.04 | 0.04 | 0.05 | 0.23 | 0.06 | 0.09 | 0.87 | 0.06 | 0.46 | 0.06 | 0.05 | 0.04 | 0.05 | 0.14 | 0.07 | 0.09 | 1.00 | 0.03 | 0.26 | 
|---|
|
| 68T 1.00 | 0.25 | 0.06 | 0.05 | 0.08 | 0.23 | 0.07 | 0.10 | 0.72 | 0.09 | 0.46 | 0.10 | 0.07 | 0.07 | 0.14 | 0.08 | 0.29 | 0.47 | 1.00 | 0.04 | 0.19 | 
|---|
|
| 69S 1.00 | 0.50 | 0.24 | 0.22 | 0.37 | 0.64 | 0.39 | 0.57 | 0.37 | 0.31 | 0.60 | 0.27 | 0.30 | 1.00 | 0.29 | 0.34 | 0.73 | 0.54 | 0.47 | 0.17 | 1.00 | 
|---|
|
| 70S 1.00 | 0.07 | 0.01 | 1.00 | 0.78 | 0.01 | 0.22 | 0.03 | 0.01 | 0.09 | 0.02 | 0.01 | 0.32 | 0.04 | 0.06 | 0.05 | 0.54 | 0.16 | 0.02 | 0.00 | 0.02 | 
|---|
|
| 71L 1.00 | 0.03 | 0.01 | 0.01 | 0.01 | 0.21 | 0.01 | 0.00 | 1.00 | 0.01 | 0.95 | 0.05 | 0.01 | 0.01 | 0.01 | 0.09 | 0.01 | 0.03 | 0.65 | 0.01 | 0.02 | 
|---|
|
| 72A 1.00 | 0.85 | 0.02 | 0.33 | 0.63 | 0.02 | 0.24 | 0.04 | 0.06 | 0.30 | 0.10 | 0.03 | 0.44 | 0.09 | 0.31 | 0.17 | 1.00 | 0.73 | 0.09 | 0.01 | 0.01 | 
|---|
|
| 73L 1.00 | 0.13 | 0.03 | 0.89 | 0.19 | 0.03 | 0.44 | 0.17 | 0.02 | 0.18 | 0.17 | 0.01 | 1.00 | 0.10 | 0.12 | 0.09 | 0.38 | 0.13 | 0.03 | 0.01 | 0.07 | 
|---|
|
| 74H 1.00 | 0.54 | 0.18 | 0.22 | 0.30 | 0.71 | 0.34 | 0.55 | 0.41 | 0.31 | 0.66 | 0.22 | 0.32 | 0.23 | 0.31 | 0.36 | 0.42 | 0.41 | 0.52 | 0.18 | 1.00 | 
|---|
|
| 75A 1.00 | 0.43 | 0.05 | 0.06 | 0.08 | 1.00 | 0.10 | 0.25 | 0.34 | 0.09 | 0.20 | 0.07 | 0.09 | 0.06 | 0.09 | 0.11 | 0.12 | 0.12 | 0.16 | 0.06 | 0.95 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 76P 1.00 | 0.03 | 0.01 | 0.01 | 0.01 | 1.00 | 0.01 | 0.00 | 0.06 | 0.00 | 0.14 | 0.03 | 0.00 | 0.12 | 0.00 | 0.00 | 0.02 | 0.02 | 0.06 | 0.13 | 0.79 | 
|---|
|
| 77S 1.00 | 1.00 | 0.17 | 0.34 | 0.43 | 0.51 | 0.59 | 0.41 | 0.33 | 0.43 | 0.58 | 0.19 | 0.41 | 0.35 | 0.35 | 0.37 | 0.76 | 0.49 | 0.47 | 0.14 | 0.73 | 
|---|
|
| 78Q 1.00 | 0.76 | 0.05 | 0.61 | 1.00 | 0.05 | 0.37 | 0.12 | 0.19 | 0.90 | 0.29 | 0.11 | 0.49 | 0.27 | 0.59 | 0.51 | 0.72 | 0.56 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 79I 1.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.18 | 0.01 | 0.00 | 1.00 | 0.01 | 0.84 | 0.12 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.11 | 0.25 | 0.00 | 0.01 | 
|---|
|
| 80V 1.00 | 0.87 | 0.10 | 0.34 | 0.55 | 0.16 | 0.23 | 0.15 | 0.44 | 0.53 | 0.45 | 0.14 | 0.30 | 0.22 | 0.38 | 0.41 | 0.48 | 0.57 | 1.00 | 0.04 | 0.18 | 
|---|
|
| 81A 1.00 | 0.68 | 0.10 | 0.33 | 0.55 | 0.31 | 0.36 | 0.35 | 0.25 | 1.00 | 0.46 | 0.14 | 0.35 | 0.22 | 0.54 | 0.81 | 0.48 | 0.46 | 0.33 | 0.09 | 0.49 | 
|---|
|
| 82A 1.00 | 0.71 | 0.02 | 0.01 | 0.02 | 0.01 | 1.00 | 0.00 | 0.01 | 0.02 | 0.02 | 0.01 | 0.01 | 0.04 | 0.01 | 0.01 | 0.09 | 0.03 | 0.12 | 0.00 | 0.01 | 
|---|
|
| 83I 1.00 | 0.13 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 1.00 | 0.00 | 0.09 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.47 | 0.00 | 0.00 | 
|---|
|
| 84K 1.00 | 0.18 | 0.01 | 0.53 | 1.00 | 0.01 | 0.19 | 0.04 | 0.04 | 0.40 | 0.07 | 0.02 | 0.21 | 0.07 | 0.16 | 0.11 | 0.17 | 0.13 | 0.13 | 0.01 | 0.01 | 
|---|
|
| 85S 1.00 | 0.72 | 0.05 | 0.90 | 0.89 | 0.04 | 0.39 | 0.11 | 0.16 | 1.00 | 0.31 | 0.09 | 0.44 | 0.24 | 0.69 | 0.51 | 0.80 | 0.56 | 0.25 | 0.02 | 0.03 | 
|---|
|
| 86R 1.00 | 0.86 | 0.13 | 0.54 | 0.90 | 0.38 | 0.44 | 0.37 | 0.42 | 1.00 | 0.58 | 0.20 | 0.51 | 0.32 | 0.63 | 0.74 | 0.72 | 0.65 | 0.61 | 0.10 | 0.51 | 
|---|
|
| 87A 1.00 | 1.00 | 0.14 | 0.02 | 0.05 | 0.05 | 0.09 | 0.02 | 0.26 | 0.05 | 0.38 | 0.06 | 0.03 | 0.08 | 0.04 | 0.03 | 0.15 | 0.17 | 0.43 | 0.01 | 0.03 | 
|---|
|
| 88D 1.00 | 0.86 | 0.11 | 0.65 | 1.00 | 0.29 | 0.45 | 0.29 | 0.31 | 0.92 | 0.49 | 0.17 | 0.55 | 0.31 | 0.63 | 0.59 | 0.80 | 0.69 | 0.43 | 0.08 | 0.39 | 
|---|
|
| 89Q 1.00 | 0.75 | 0.06 | 0.62 | 1.00 | 0.06 | 0.38 | 0.13 | 0.19 | 0.92 | 0.31 | 0.13 | 0.49 | 0.28 | 0.60 | 0.53 | 0.73 | 0.57 | 0.29 | 0.02 | 0.05 | 
|---|
|
| 90L 0.96 | 0.44 | 0.14 | 0.17 | 0.22 | 0.57 | 0.27 | 0.51 | 0.32 | 0.24 | 0.66 | 0.18 | 0.25 | 0.17 | 0.30 | 0.34 | 0.33 | 0.34 | 0.41 | 0.15 | 1.00 | 
|---|
|
| 91G 0.96 | 0.55 | 0.07 | 0.67 | 0.64 | 0.19 | 0.89 | 0.24 | 0.20 | 1.00 | 0.32 | 0.11 | 0.35 | 0.21 | 0.52 | 0.46 | 0.51 | 0.42 | 0.28 | 0.05 | 0.25 | 
|---|
|
| 92A 0.96 | 0.40 | 0.11 | 0.12 | 0.17 | 0.45 | 0.20 | 0.33 | 0.27 | 0.23 | 0.39 | 0.17 | 0.21 | 0.12 | 0.18 | 0.21 | 0.24 | 0.24 | 0.30 | 0.11 | 1.00 | 
|---|
|
| 93S 1.00 | 0.48 | 0.16 | 0.25 | 0.55 | 0.70 | 0.34 | 0.73 | 0.35 | 0.30 | 0.58 | 0.20 | 1.00 | 0.20 | 0.29 | 0.33 | 0.69 | 0.76 | 0.45 | 0.16 | 0.96 | 
|---|
|
| 94V 1.00 | 0.16 | 0.04 | 0.01 | 0.03 | 0.11 | 0.02 | 0.01 | 1.00 | 0.04 | 0.84 | 0.23 | 0.02 | 0.22 | 0.03 | 0.03 | 0.07 | 0.12 | 0.90 | 0.01 | 0.03 | 
|---|
|
| 95V 1.00 | 0.09 | 0.03 | 0.03 | 0.04 | 0.23 | 0.05 | 0.08 | 0.94 | 0.05 | 0.60 | 0.15 | 0.05 | 0.03 | 0.15 | 0.06 | 0.07 | 0.19 | 1.00 | 0.03 | 0.27 | 
|---|
|
| 96V 1.00 | 0.25 | 0.07 | 0.07 | 0.11 | 0.26 | 0.11 | 0.24 | 0.63 | 0.12 | 1.00 | 0.12 | 0.18 | 0.09 | 0.11 | 0.13 | 0.22 | 0.19 | 0.62 | 0.06 | 0.32 | 
|---|
|
| 97S 0.96 | 0.58 | 0.22 | 0.22 | 0.29 | 0.72 | 0.37 | 0.54 | 0.40 | 0.31 | 0.67 | 0.24 | 0.32 | 0.21 | 0.30 | 0.36 | 0.53 | 0.41 | 0.51 | 0.19 | 1.00 | 
|---|
|
| 98M 0.89 | 0.51 | 0.18 | 0.21 | 0.28 | 0.72 | 0.33 | 0.55 | 0.39 | 0.30 | 0.65 | 0.25 | 0.40 | 0.21 | 0.30 | 0.35 | 0.42 | 0.43 | 0.50 | 0.19 | 1.00 | 
|---|
|
| 99V 0.93 | 0.53 | 0.18 | 0.22 | 0.30 | 0.70 | 0.34 | 0.54 | 0.40 | 0.32 | 0.66 | 0.22 | 0.33 | 0.21 | 0.33 | 0.36 | 0.48 | 0.41 | 0.53 | 0.18 | 1.00 | 
|---|
|
| 100E 0.93 | 0.41 | 0.10 | 0.89 | 1.00 | 0.32 | 0.39 | 0.35 | 0.31 | 0.36 | 0.36 | 0.13 | 0.26 | 0.16 | 0.28 | 0.29 | 0.36 | 0.53 | 0.30 | 0.09 | 0.45 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 101R 0.79 | 0.52 | 0.18 | 0.22 | 0.31 | 0.69 | 0.34 | 0.55 | 0.39 | 0.31 | 0.65 | 0.22 | 0.33 | 0.22 | 0.32 | 0.38 | 0.42 | 0.40 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 102S 0.93 | 0.79 | 0.19 | 0.45 | 0.66 | 0.71 | 0.48 | 0.59 | 0.46 | 0.64 | 0.76 | 0.26 | 0.50 | 0.31 | 0.52 | 0.55 | 0.69 | 0.61 | 0.60 | 0.19 | 1.00 | 
|---|
|
| 103G 0.86 | 0.75 | 0.09 | 0.72 | 0.90 | 0.21 | 1.00 | 0.28 | 0.24 | 0.79 | 0.38 | 0.14 | 0.54 | 0.31 | 0.50 | 0.47 | 0.70 | 0.59 | 0.33 | 0.07 | 0.27 | 
|---|
|
| 104V 0.79 | 0.65 | 0.19 | 0.32 | 0.45 | 0.71 | 0.39 | 0.56 | 0.45 | 0.44 | 0.71 | 0.24 | 0.39 | 0.26 | 0.39 | 0.43 | 0.53 | 0.48 | 0.59 | 0.19 | 1.00 | 
|---|
|
| 105E 0.86 | 0.59 | 0.13 | 0.44 | 1.00 | 0.50 | 0.35 | 0.38 | 0.32 | 0.52 | 0.51 | 0.22 | 0.38 | 0.28 | 0.49 | 0.41 | 0.61 | 0.46 | 0.46 | 0.13 | 0.63 | 
|---|
|
| 106A 0.93 | 0.76 | 0.07 | 0.56 | 0.77 | 0.16 | 0.33 | 0.18 | 0.21 | 1.00 | 0.36 | 0.12 | 0.41 | 0.24 | 0.51 | 0.46 | 0.60 | 0.56 | 0.30 | 0.05 | 0.20 | 
|---|
|
| 107C 0.93 | 0.55 | 0.22 | 0.25 | 0.53 | 0.70 | 0.35 | 0.55 | 0.42 | 0.35 | 0.68 | 0.23 | 0.34 | 0.22 | 0.33 | 0.40 | 0.45 | 0.43 | 0.52 | 0.19 | 1.00 | 
|---|
|
| 108K 0.89 | 0.97 | 0.19 | 0.67 | 0.95 | 0.65 | 0.55 | 0.57 | 0.47 | 1.00 | 0.82 | 0.27 | 0.61 | 0.37 | 0.69 | 0.73 | 0.86 | 0.74 | 0.66 | 0.18 | 0.90 | 
|---|
|
| 109A 0.82 | 0.92 | 0.14 | 0.56 | 1.00 | 0.44 | 0.46 | 0.44 | 0.36 | 0.85 | 0.59 | 0.21 | 0.57 | 0.31 | 0.63 | 0.57 | 0.75 | 0.65 | 0.49 | 0.12 | 0.60 | 
|---|
|
| 110A 0.82 | 0.52 | 0.18 | 0.20 | 0.27 | 0.70 | 0.33 | 0.54 | 0.39 | 0.29 | 0.65 | 0.22 | 0.31 | 0.20 | 0.29 | 0.35 | 0.40 | 0.39 | 0.51 | 0.18 | 1.00 | 
|---|
|
| 111V 0.86 | 0.33 | 0.13 | 0.15 | 0.19 | 0.53 | 0.22 | 0.35 | 0.86 | 0.20 | 1.00 | 0.16 | 0.21 | 0.15 | 0.20 | 0.24 | 0.27 | 0.41 | 0.89 | 0.14 | 0.64 | 
|---|
|
| 112H 0.89 | 0.76 | 0.13 | 0.53 | 1.00 | 0.39 | 0.40 | 0.47 | 0.32 | 0.72 | 0.52 | 0.18 | 0.64 | 0.31 | 0.54 | 0.53 | 0.65 | 0.55 | 0.43 | 0.11 | 0.53 | 
|---|
|
| 113N 0.89 | 0.53 | 0.18 | 0.22 | 0.30 | 0.70 | 0.34 | 0.54 | 0.40 | 0.32 | 0.65 | 0.23 | 0.34 | 0.21 | 0.31 | 0.36 | 0.43 | 0.42 | 0.52 | 0.18 | 1.00 | 
|---|
|
| 114L 0.89 | 0.11 | 0.04 | 0.05 | 0.06 | 0.27 | 0.08 | 0.12 | 0.09 | 0.07 | 1.00 | 0.12 | 0.07 | 0.05 | 0.07 | 0.08 | 0.15 | 0.09 | 0.18 | 0.05 | 0.21 | 
|---|
|
| 115L 0.93 | 0.19 | 0.07 | 0.08 | 0.11 | 0.36 | 0.13 | 0.20 | 0.32 | 0.16 | 1.00 | 0.09 | 0.12 | 0.08 | 0.11 | 0.20 | 0.15 | 0.22 | 0.28 | 0.07 | 0.37 | 
|---|
|
| 116A 0.96 | 0.79 | 0.06 | 0.62 | 1.00 | 0.08 | 0.40 | 0.14 | 0.20 | 0.91 | 0.32 | 0.11 | 0.50 | 0.28 | 0.59 | 0.54 | 0.74 | 0.58 | 0.29 | 0.02 | 0.07 | 
|---|
|
| 117Q 1.00 | 0.07 | 0.01 | 0.04 | 0.17 | 0.01 | 0.12 | 0.10 | 0.03 | 1.00 | 0.05 | 0.10 | 0.06 | 0.04 | 0.46 | 0.47 | 0.07 | 0.07 | 0.04 | 0.01 | 0.02 | 
|---|
|
| 118R 1.00 | 0.35 | 0.03 | 0.29 | 0.62 | 0.04 | 0.37 | 0.10 | 0.10 | 0.70 | 0.17 | 0.11 | 0.48 | 0.15 | 0.78 | 1.00 | 0.34 | 0.28 | 0.14 | 0.02 | 0.05 | 
|---|
|
| 119V 1.00 | 0.11 | 0.14 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.07 | 0.01 | 0.10 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.04 | 1.00 | 0.00 | 0.07 | 
|---|
|
| 120S 1.00 | 0.44 | 0.02 | 1.00 | 0.36 | 0.02 | 0.14 | 0.05 | 0.07 | 0.33 | 0.11 | 0.04 | 0.25 | 0.11 | 0.28 | 0.19 | 0.67 | 0.38 | 0.18 | 0.01 | 0.02 | 
|---|
|
| 121G 1.00 | 0.12 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 122L 1.00 | 0.11 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 1.00 | 0.01 | 0.65 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.57 | 0.00 | 0.01 | 
|---|
|
| 123I 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 1.00 | 0.00 | 0.26 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 
|---|
|
| 124I 1.00 | 0.39 | 0.16 | 0.12 | 0.17 | 0.69 | 0.20 | 0.31 | 0.86 | 0.18 | 0.62 | 0.16 | 0.18 | 0.13 | 0.17 | 0.21 | 0.24 | 0.27 | 1.00 | 0.11 | 0.83 | 
|---|
|
| 125N 1.00 | 0.55 | 0.18 | 0.16 | 0.23 | 0.59 | 0.24 | 0.45 | 0.60 | 0.24 | 1.00 | 0.40 | 0.29 | 0.19 | 0.24 | 0.27 | 0.32 | 0.41 | 0.86 | 0.14 | 0.74 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 126Y 1.00 | 1.00 | 0.10 | 0.16 | 0.11 | 0.05 | 0.65 | 0.04 | 0.05 | 0.12 | 0.10 | 0.05 | 0.16 | 0.25 | 0.08 | 0.08 | 0.61 | 0.21 | 0.16 | 0.02 | 0.08 | 
|---|
|
| 127P 0.96 | 0.75 | 0.06 | 0.62 | 1.00 | 0.06 | 0.43 | 0.14 | 0.19 | 0.98 | 0.31 | 0.11 | 0.50 | 0.31 | 0.60 | 0.53 | 0.76 | 0.58 | 0.29 | 0.02 | 0.06 | 
|---|
|
| 128L 0.93 | 0.54 | 0.18 | 0.23 | 0.31 | 0.70 | 0.34 | 0.54 | 0.40 | 0.33 | 0.67 | 0.23 | 0.33 | 0.21 | 0.32 | 0.37 | 0.43 | 0.41 | 0.51 | 0.18 | 1.00 | 
|---|
|
| 129D 0.96 | 0.53 | 0.18 | 0.22 | 0.30 | 0.70 | 0.34 | 0.54 | 0.40 | 0.31 | 0.66 | 0.22 | 0.32 | 0.21 | 0.31 | 0.36 | 0.42 | 0.40 | 0.51 | 0.18 | 1.00 | 
|---|
|
| 130D 1.00 | 0.79 | 0.06 | 0.67 | 1.00 | 0.06 | 0.38 | 0.13 | 0.20 | 0.93 | 0.32 | 0.11 | 0.50 | 0.30 | 0.59 | 0.54 | 0.79 | 0.64 | 0.30 | 0.02 | 0.06 | 
|---|
|
| 131Q 0.96 | 0.14 | 0.01 | 1.00 | 0.88 | 0.02 | 0.17 | 0.03 | 0.04 | 0.17 | 0.06 | 0.02 | 0.09 | 0.05 | 0.42 | 0.10 | 0.13 | 0.27 | 0.06 | 0.01 | 0.02 | 
|---|
|
| 132D 0.93 | 0.39 | 0.03 | 1.00 | 0.97 | 0.03 | 0.16 | 0.06 | 0.08 | 0.56 | 0.13 | 0.05 | 0.31 | 0.22 | 0.34 | 0.22 | 0.30 | 0.37 | 0.12 | 0.01 | 0.02 | 
|---|
|
| 133A 0.79 | 0.93 | 0.13 | 0.64 | 1.00 | 0.37 | 0.48 | 0.37 | 0.35 | 0.93 | 0.56 | 0.20 | 0.57 | 0.34 | 0.66 | 0.62 | 0.83 | 0.67 | 0.49 | 0.10 | 0.51 | 
|---|
|
| 134I 0.96 | 0.53 | 0.17 | 0.20 | 0.27 | 0.71 | 0.32 | 0.56 | 0.53 | 0.28 | 0.76 | 0.22 | 0.30 | 0.20 | 0.29 | 0.39 | 0.39 | 0.38 | 0.49 | 0.18 | 1.00 | 
|---|
|
| 135A 1.00 | 0.79 | 0.07 | 0.62 | 1.00 | 0.11 | 0.40 | 0.17 | 0.22 | 0.92 | 0.35 | 0.12 | 0.50 | 0.29 | 0.60 | 0.55 | 0.75 | 0.60 | 0.32 | 0.03 | 0.13 | 
|---|
|
| 136V 1.00 | 0.91 | 0.10 | 0.60 | 1.00 | 0.25 | 0.44 | 0.28 | 0.29 | 0.87 | 0.45 | 0.15 | 0.51 | 0.29 | 0.60 | 0.56 | 0.77 | 0.60 | 0.44 | 0.07 | 0.35 | 
|---|
|
| 137E 1.00 | 0.52 | 0.18 | 0.21 | 0.29 | 0.70 | 0.33 | 0.54 | 0.40 | 0.31 | 0.66 | 0.22 | 0.31 | 0.21 | 0.30 | 0.36 | 0.41 | 0.40 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 138A 1.00 | 0.18 | 0.02 | 0.01 | 0.02 | 0.23 | 0.02 | 0.03 | 0.37 | 0.06 | 1.00 | 0.22 | 0.02 | 0.03 | 0.04 | 0.03 | 0.03 | 0.05 | 0.20 | 0.02 | 0.05 | 
|---|
|
| 139A 1.00 | 0.76 | 0.05 | 0.62 | 1.00 | 0.05 | 0.38 | 0.12 | 0.18 | 0.93 | 0.30 | 0.10 | 0.50 | 0.27 | 0.58 | 0.53 | 0.73 | 0.57 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 140C 1.00 | 0.76 | 0.06 | 0.62 | 1.00 | 0.05 | 0.38 | 0.12 | 0.19 | 0.92 | 0.30 | 0.11 | 0.49 | 0.27 | 0.59 | 0.53 | 0.73 | 0.57 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 141T 1.00 | 0.80 | 0.05 | 0.63 | 1.00 | 0.06 | 0.38 | 0.13 | 0.20 | 0.94 | 0.34 | 0.12 | 0.49 | 0.27 | 0.61 | 0.56 | 0.77 | 0.62 | 0.30 | 0.02 | 0.05 | 
|---|
|
| 142N 0.89 | 0.85 | 0.11 | 0.64 | 1.00 | 0.27 | 0.46 | 0.28 | 0.30 | 0.95 | 0.49 | 0.17 | 0.57 | 0.33 | 0.63 | 0.59 | 0.80 | 0.66 | 0.42 | 0.08 | 0.36 | 
|---|
|
| 143V 0.86 | 0.59 | 0.18 | 0.27 | 0.38 | 0.70 | 0.38 | 0.55 | 0.42 | 0.39 | 0.69 | 0.23 | 0.36 | 0.24 | 0.35 | 0.40 | 0.47 | 0.46 | 0.56 | 0.19 | 1.00 | 
|---|
|
| 144P 0.96 | 0.43 | 0.14 | 0.19 | 0.27 | 0.53 | 0.27 | 0.41 | 0.37 | 0.32 | 0.51 | 0.32 | 0.33 | 1.00 | 0.26 | 0.29 | 0.35 | 0.39 | 0.44 | 0.14 | 0.75 | 
|---|
|
| 145A 0.96 | 0.44 | 0.04 | 0.04 | 0.06 | 0.25 | 0.07 | 0.11 | 0.21 | 0.06 | 0.30 | 0.05 | 0.06 | 0.04 | 0.06 | 0.07 | 0.08 | 0.14 | 1.00 | 0.04 | 0.20 | 
|---|
|
| 146L 1.00 | 0.02 | 0.08 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.14 | 0.00 | 0.49 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 147F 1.00 | 0.12 | 0.01 | 0.01 | 0.01 | 0.58 | 0.01 | 0.01 | 0.53 | 0.02 | 1.00 | 0.09 | 0.01 | 0.02 | 0.02 | 0.01 | 0.01 | 0.04 | 0.59 | 0.01 | 0.02 | 
|---|
|
| 148L 1.00 | 0.60 | 0.18 | 0.23 | 0.32 | 0.73 | 0.36 | 0.54 | 0.54 | 0.33 | 0.78 | 0.23 | 0.39 | 0.22 | 0.32 | 0.37 | 0.46 | 0.42 | 0.71 | 0.19 | 1.00 | 
|---|
|
| 149D 1.00 | 0.74 | 0.05 | 1.00 | 0.93 | 0.05 | 0.60 | 0.12 | 0.16 | 0.82 | 0.27 | 0.09 | 0.59 | 0.25 | 0.52 | 0.58 | 0.72 | 0.55 | 0.25 | 0.02 | 0.04 | 
|---|
|
| 150V 1.00 | 0.57 | 0.18 | 0.25 | 0.35 | 0.70 | 0.36 | 0.55 | 0.41 | 0.36 | 0.67 | 0.23 | 0.34 | 0.22 | 0.34 | 0.39 | 0.46 | 0.44 | 0.53 | 0.18 | 1.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 151S 1.00 | 0.75 | 0.06 | 0.63 | 1.00 | 0.06 | 0.38 | 0.13 | 0.20 | 0.92 | 0.31 | 0.11 | 0.49 | 0.28 | 0.58 | 0.52 | 0.75 | 0.57 | 0.30 | 0.02 | 0.06 | 
|---|
|
| 152D 1.00 | 0.69 | 0.05 | 0.76 | 1.00 | 0.05 | 0.42 | 0.11 | 0.17 | 0.86 | 0.30 | 0.10 | 0.45 | 0.39 | 0.54 | 0.47 | 0.70 | 0.54 | 0.26 | 0.02 | 0.04 | 
|---|
|
| 153Q 1.00 | 0.74 | 0.05 | 0.67 | 1.00 | 0.05 | 0.43 | 0.12 | 0.18 | 0.91 | 0.29 | 0.10 | 0.50 | 0.26 | 0.64 | 0.52 | 0.71 | 0.55 | 0.27 | 0.02 | 0.04 | 
|---|
|
| 154T 1.00 | 1.00 | 0.19 | 0.64 | 0.98 | 0.66 | 0.57 | 0.57 | 0.48 | 0.94 | 0.79 | 0.27 | 0.63 | 0.38 | 0.69 | 0.69 | 0.89 | 0.77 | 0.65 | 0.17 | 0.91 | 
|---|
|
| 155P 1.00 | 0.69 | 0.05 | 0.58 | 1.00 | 0.04 | 0.41 | 0.11 | 0.17 | 0.84 | 0.27 | 0.09 | 0.44 | 0.35 | 0.62 | 0.48 | 0.65 | 0.53 | 0.25 | 0.02 | 0.03 | 
|---|
|
| 156I 1.00 | 0.53 | 0.19 | 0.20 | 0.26 | 0.70 | 0.32 | 0.56 | 0.48 | 0.28 | 0.68 | 0.21 | 0.31 | 0.20 | 0.28 | 0.34 | 0.39 | 0.39 | 0.51 | 0.18 | 1.00 | 
|---|
|
| 157N 1.00 | 0.78 | 0.06 | 0.85 | 1.00 | 0.06 | 0.48 | 0.14 | 0.19 | 0.93 | 0.30 | 0.11 | 0.71 | 0.55 | 0.59 | 0.62 | 0.86 | 0.69 | 0.28 | 0.02 | 0.05 | 
|---|
|
| 158S 1.00 | 0.56 | 0.25 | 0.23 | 0.28 | 0.73 | 0.36 | 0.53 | 0.38 | 0.29 | 0.63 | 0.22 | 0.38 | 0.21 | 0.29 | 0.34 | 0.70 | 0.44 | 0.49 | 0.18 | 1.00 | 
|---|
|
| 159I 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.64 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 160I 1.00 | 0.80 | 0.08 | 0.64 | 1.00 | 0.11 | 0.41 | 0.17 | 0.24 | 0.93 | 0.36 | 0.12 | 0.54 | 0.29 | 0.60 | 0.54 | 0.81 | 0.67 | 0.33 | 0.03 | 0.13 | 
|---|
|
| 161F 1.00 | 0.26 | 0.07 | 0.07 | 0.10 | 0.46 | 0.10 | 0.15 | 1.00 | 0.11 | 0.93 | 0.18 | 0.11 | 0.24 | 0.11 | 0.11 | 0.31 | 0.32 | 0.45 | 0.06 | 0.27 | 
|---|
|
| 162S 1.00 | 0.08 | 0.00 | 1.00 | 0.02 | 0.00 | 0.04 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.13 | 0.01 | 0.01 | 0.01 | 0.21 | 0.02 | 0.00 | 0.00 | 0.01 | 
|---|
|
| 163H 1.00 | 0.50 | 0.17 | 0.21 | 0.27 | 0.70 | 0.33 | 0.54 | 0.39 | 0.29 | 0.64 | 0.22 | 0.31 | 0.20 | 0.29 | 0.34 | 0.40 | 0.39 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 164E 1.00 | 0.74 | 0.07 | 0.55 | 1.00 | 0.16 | 0.37 | 0.21 | 0.24 | 0.86 | 0.37 | 0.12 | 0.46 | 0.26 | 0.55 | 0.57 | 0.68 | 0.54 | 0.33 | 0.04 | 0.21 | 
|---|
|
| 165D 1.00 | 0.75 | 0.05 | 0.63 | 1.00 | 0.05 | 0.38 | 0.12 | 0.19 | 0.92 | 0.30 | 0.10 | 0.49 | 0.27 | 0.59 | 0.52 | 0.73 | 0.57 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 166G 1.00 | 1.00 | 0.02 | 0.02 | 0.02 | 0.01 | 0.74 | 0.00 | 0.09 | 0.02 | 0.02 | 0.01 | 0.02 | 0.13 | 0.02 | 0.02 | 0.19 | 0.04 | 0.04 | 0.00 | 0.01 | 
|---|
|
| 167T 1.00 | 1.00 | 0.05 | 0.45 | 0.58 | 0.08 | 0.43 | 0.11 | 0.28 | 0.54 | 0.22 | 0.20 | 0.31 | 0.18 | 0.35 | 0.32 | 0.94 | 0.92 | 0.35 | 0.03 | 0.10 | 
|---|
|
| 168R 1.00 | 0.49 | 0.14 | 0.23 | 0.45 | 0.59 | 0.30 | 0.44 | 0.33 | 0.67 | 0.55 | 0.19 | 0.30 | 0.20 | 0.51 | 0.96 | 0.50 | 0.44 | 0.42 | 0.21 | 1.00 | 
|---|
|
| 169L 1.00 | 0.41 | 0.03 | 0.55 | 1.00 | 0.04 | 0.19 | 0.08 | 0.09 | 0.48 | 0.16 | 0.06 | 0.24 | 0.18 | 0.38 | 0.24 | 0.35 | 0.28 | 0.15 | 0.01 | 0.04 | 
|---|
|
| 170G 1.00 | 1.00 | 0.07 | 0.02 | 0.02 | 0.01 | 0.30 | 0.00 | 0.17 | 0.02 | 0.02 | 0.01 | 0.02 | 0.06 | 0.02 | 0.02 | 0.22 | 0.04 | 0.04 | 0.00 | 0.01 | 
|---|
|
| 171V 1.00 | 0.28 | 0.03 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.42 | 0.02 | 0.25 | 0.03 | 0.01 | 0.03 | 0.01 | 0.01 | 0.02 | 0.58 | 1.00 | 0.00 | 0.01 | 
|---|
|
| 172E 0.96 | 0.60 | 0.08 | 0.55 | 1.00 | 0.05 | 0.30 | 0.13 | 0.15 | 0.80 | 0.26 | 0.08 | 0.47 | 0.21 | 0.47 | 0.48 | 0.57 | 0.51 | 0.23 | 0.02 | 0.04 | 
|---|
|
| 173H 1.00 | 0.48 | 0.16 | 0.19 | 0.25 | 0.67 | 0.30 | 0.80 | 0.37 | 0.29 | 0.65 | 0.25 | 0.28 | 0.18 | 0.28 | 0.33 | 0.38 | 0.37 | 0.45 | 0.17 | 1.00 | 
|---|
|
| 174L 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.01 | 0.00 | 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.12 | 
|---|
|
| 175V 1.00 | 0.40 | 0.08 | 0.11 | 0.15 | 0.43 | 0.22 | 0.25 | 1.00 | 0.25 | 0.86 | 0.12 | 0.15 | 0.10 | 0.25 | 0.17 | 0.20 | 0.20 | 0.91 | 0.09 | 0.46 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 176A 1.00 | 0.75 | 0.05 | 0.62 | 1.00 | 0.05 | 0.37 | 0.12 | 0.18 | 0.91 | 0.30 | 0.10 | 0.49 | 0.27 | 0.58 | 0.52 | 0.73 | 0.56 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 177L 1.00 | 0.76 | 0.06 | 0.62 | 1.00 | 0.08 | 0.39 | 0.14 | 0.20 | 0.93 | 0.33 | 0.11 | 0.50 | 0.28 | 0.59 | 0.53 | 0.74 | 0.58 | 0.30 | 0.02 | 0.08 | 
|---|
|
| 178G 1.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 1.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 179H 1.00 | 0.51 | 0.22 | 0.20 | 0.27 | 0.69 | 0.32 | 0.83 | 0.43 | 0.31 | 0.63 | 0.22 | 0.35 | 0.20 | 0.29 | 0.34 | 0.39 | 0.38 | 0.52 | 0.18 | 1.00 | 
|---|
|
| 180Q 1.00 | 0.19 | 0.01 | 0.22 | 0.26 | 0.02 | 0.11 | 0.04 | 0.05 | 1.00 | 0.08 | 0.03 | 0.45 | 0.08 | 0.75 | 0.40 | 0.19 | 0.53 | 0.07 | 0.01 | 0.02 | 
|---|
|
| 181Q 1.00 | 0.29 | 0.02 | 0.61 | 0.39 | 0.02 | 0.18 | 0.20 | 0.07 | 0.79 | 0.12 | 0.04 | 0.39 | 0.12 | 0.60 | 1.00 | 0.36 | 0.23 | 0.11 | 0.01 | 0.03 | 
|---|
|
| 182I 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 1.00 | 0.00 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.16 | 0.00 | 0.00 | 
|---|
|
| 183A 1.00 | 1.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.67 | 0.00 | 0.01 | 0.02 | 0.08 | 0.01 | 0.01 | 0.04 | 0.01 | 0.01 | 0.08 | 0.03 | 0.02 | 0.00 | 0.00 | 
|---|
|
| 184L 1.00 | 0.06 | 0.02 | 0.02 | 0.03 | 0.95 | 0.03 | 0.04 | 0.22 | 0.03 | 1.00 | 0.06 | 0.03 | 0.02 | 0.03 | 0.03 | 0.04 | 0.14 | 0.09 | 0.04 | 0.60 | 
|---|
|
| 185L 1.00 | 0.31 | 0.02 | 0.01 | 0.02 | 0.05 | 0.01 | 0.00 | 1.00 | 0.02 | 0.85 | 0.05 | 0.01 | 0.02 | 0.01 | 0.01 | 0.02 | 0.07 | 0.85 | 0.01 | 0.02 | 
|---|
|
| 186A 1.00 | 0.84 | 0.09 | 0.61 | 1.00 | 0.12 | 0.50 | 0.17 | 0.24 | 0.93 | 0.38 | 0.14 | 0.50 | 0.28 | 0.59 | 0.53 | 0.82 | 0.59 | 0.34 | 0.04 | 0.15 | 
|---|
|
| 187G 1.00 | 0.04 | 0.00 | 0.01 | 0.01 | 0.00 | 1.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.16 | 0.06 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 188P 1.00 | 0.73 | 0.05 | 0.67 | 1.00 | 0.05 | 0.35 | 0.11 | 0.24 | 0.91 | 0.28 | 0.10 | 0.56 | 0.75 | 0.66 | 0.54 | 0.85 | 0.56 | 0.33 | 0.02 | 0.04 | 
|---|
|
| 189L 1.00 | 0.70 | 0.15 | 0.59 | 1.00 | 0.54 | 0.40 | 0.47 | 0.36 | 0.64 | 0.60 | 0.21 | 0.43 | 0.29 | 0.53 | 0.48 | 0.58 | 0.51 | 0.48 | 0.15 | 0.76 | 
|---|
|
| 190S 1.00 | 0.74 | 0.05 | 0.68 | 1.00 | 0.04 | 0.41 | 0.11 | 0.17 | 0.93 | 0.27 | 0.09 | 0.46 | 0.24 | 0.52 | 0.55 | 0.82 | 0.56 | 0.25 | 0.02 | 0.03 | 
|---|
|
| 191S 1.00 | 0.69 | 0.19 | 0.37 | 0.53 | 0.71 | 0.42 | 0.57 | 0.44 | 0.53 | 0.72 | 0.24 | 0.43 | 0.27 | 0.44 | 0.48 | 0.59 | 0.53 | 0.57 | 0.19 | 1.00 | 
|---|
|
| 192V 1.00 | 0.56 | 0.18 | 0.24 | 0.34 | 0.70 | 0.36 | 0.55 | 0.44 | 0.36 | 0.66 | 0.23 | 0.33 | 0.22 | 0.32 | 0.38 | 0.45 | 0.43 | 0.59 | 0.18 | 1.00 | 
|---|
|
| 193S 1.00 | 0.75 | 0.05 | 0.75 | 0.91 | 0.04 | 0.32 | 0.10 | 0.16 | 0.85 | 0.25 | 0.09 | 0.72 | 0.38 | 0.50 | 0.44 | 1.00 | 0.54 | 0.28 | 0.01 | 0.03 | 
|---|
|
| 194A 1.00 | 0.90 | 0.07 | 0.63 | 1.00 | 0.14 | 0.46 | 0.18 | 0.22 | 0.91 | 0.37 | 0.12 | 0.53 | 0.28 | 0.60 | 0.56 | 0.78 | 0.59 | 0.37 | 0.04 | 0.14 | 
|---|
|
| 195R 1.00 | 0.76 | 0.05 | 0.63 | 1.00 | 0.06 | 0.36 | 0.12 | 0.18 | 0.93 | 0.29 | 0.10 | 0.50 | 0.26 | 0.75 | 0.66 | 0.74 | 0.61 | 0.30 | 0.05 | 0.07 | 
|---|
|
| 196L 1.00 | 0.87 | 0.13 | 0.65 | 1.00 | 0.40 | 0.48 | 0.37 | 0.36 | 0.91 | 0.60 | 0.20 | 0.56 | 0.33 | 0.64 | 0.62 | 0.80 | 0.66 | 0.49 | 0.11 | 0.54 | 
|---|
|
| 197R 1.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.28 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 1.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.00 | 
|---|
|
| 198L 1.00 | 0.39 | 0.12 | 0.17 | 0.34 | 0.48 | 0.24 | 0.37 | 0.39 | 0.35 | 1.00 | 0.23 | 0.23 | 0.15 | 0.23 | 0.31 | 0.31 | 0.35 | 0.39 | 0.13 | 0.74 | 
|---|
|
| 199A 1.00 | 0.83 | 0.05 | 0.62 | 1.00 | 0.05 | 0.36 | 0.12 | 0.18 | 0.91 | 0.30 | 0.10 | 0.49 | 0.27 | 0.58 | 0.53 | 0.70 | 0.56 | 0.32 | 0.02 | 0.04 | 
|---|
|
| 200G 1.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.08 | 0.01 | 0.01 | 0.00 | 0.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 201W 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.92 | 0.00 | 0.00 | 0.02 | 0.00 | 0.10 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.39 | 1.00 | 
|---|
|
| 202H 0.96 | 0.66 | 0.19 | 0.34 | 0.49 | 0.70 | 0.40 | 0.58 | 0.43 | 0.51 | 0.71 | 0.24 | 0.41 | 0.26 | 0.42 | 0.46 | 0.55 | 0.51 | 0.56 | 0.19 | 1.00 | 
|---|
|
| 203K 0.96 | 0.67 | 0.04 | 0.70 | 0.99 | 0.04 | 0.28 | 0.09 | 0.14 | 1.00 | 0.22 | 0.08 | 0.43 | 0.20 | 0.50 | 0.62 | 0.66 | 0.42 | 0.21 | 0.02 | 0.03 | 
|---|
|
| 204Y 0.96 | 0.54 | 0.17 | 0.20 | 0.26 | 0.68 | 0.32 | 0.52 | 0.38 | 0.28 | 0.63 | 0.21 | 0.30 | 0.20 | 0.28 | 0.33 | 0.39 | 0.39 | 0.49 | 0.18 | 1.00 | 
|---|
|
| 205L 1.00 | 0.09 | 0.07 | 0.02 | 0.02 | 0.07 | 0.11 | 0.03 | 0.09 | 0.02 | 1.00 | 0.20 | 0.02 | 0.03 | 0.02 | 0.03 | 0.10 | 0.04 | 0.16 | 0.01 | 0.06 | 
|---|
|
| 206T 1.00 | 0.76 | 0.05 | 0.61 | 1.00 | 0.06 | 0.37 | 0.14 | 0.19 | 0.92 | 0.31 | 0.11 | 0.49 | 0.27 | 0.58 | 0.53 | 0.72 | 0.59 | 0.28 | 0.02 | 0.05 | 
|---|
|
| 207R 1.00 | 0.44 | 0.02 | 0.39 | 1.00 | 0.02 | 0.17 | 0.05 | 0.08 | 0.51 | 0.20 | 0.05 | 0.22 | 0.12 | 0.33 | 0.61 | 0.38 | 0.25 | 0.13 | 0.01 | 0.02 | 
|---|
|
| 208N 1.00 | 0.83 | 0.05 | 0.60 | 1.00 | 0.06 | 0.37 | 0.22 | 0.18 | 0.95 | 0.31 | 0.12 | 0.60 | 0.26 | 0.58 | 0.51 | 0.75 | 0.55 | 0.28 | 0.02 | 0.05 | 
|---|
|
| 209Q 1.00 | 0.69 | 0.04 | 0.67 | 0.98 | 0.04 | 1.00 | 0.11 | 0.15 | 0.76 | 0.24 | 0.09 | 0.70 | 0.32 | 0.82 | 0.42 | 0.61 | 0.58 | 0.23 | 0.01 | 0.04 | 
|---|
|
| 210I 1.00 | 0.10 | 0.02 | 0.01 | 0.02 | 0.06 | 0.01 | 0.09 | 1.00 | 0.02 | 0.74 | 0.08 | 0.01 | 0.09 | 0.02 | 0.02 | 0.02 | 0.07 | 0.44 | 0.01 | 0.02 | 
|---|
|
| 211Q 1.00 | 0.63 | 0.04 | 0.83 | 1.00 | 0.04 | 0.32 | 0.10 | 0.24 | 0.86 | 0.25 | 0.09 | 0.48 | 0.31 | 0.78 | 0.52 | 0.61 | 0.48 | 0.24 | 0.01 | 0.03 | 
|---|
|
| 212P 0.96 | 0.74 | 0.19 | 0.51 | 0.88 | 0.68 | 0.48 | 0.60 | 0.44 | 0.65 | 0.72 | 0.25 | 0.46 | 0.59 | 0.48 | 0.51 | 0.63 | 0.57 | 0.57 | 0.18 | 1.00 | 
|---|
|
| 213I 1.00 | 0.75 | 0.05 | 0.62 | 1.00 | 0.05 | 0.38 | 0.12 | 0.19 | 0.92 | 0.30 | 0.11 | 0.49 | 0.27 | 0.58 | 0.52 | 0.73 | 0.57 | 0.29 | 0.02 | 0.04 | 
|---|
|
| 214A 1.00 | 0.53 | 0.17 | 0.22 | 0.29 | 0.71 | 0.33 | 0.54 | 0.39 | 0.30 | 0.69 | 0.22 | 0.31 | 0.21 | 0.30 | 0.35 | 0.40 | 0.39 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 215E 1.00 | 0.16 | 0.03 | 0.04 | 0.16 | 0.07 | 0.04 | 0.03 | 0.84 | 0.07 | 0.32 | 0.07 | 0.04 | 0.04 | 0.05 | 0.08 | 0.12 | 0.13 | 1.00 | 0.01 | 0.05 | 
|---|
|
| 216R 1.00 | 0.51 | 0.18 | 0.20 | 0.28 | 0.72 | 0.33 | 0.54 | 0.39 | 0.29 | 0.65 | 0.22 | 0.31 | 0.20 | 0.30 | 0.36 | 0.40 | 0.40 | 0.51 | 0.19 | 1.00 | 
|---|
|
| 217E 1.00 | 0.79 | 0.08 | 0.62 | 1.00 | 0.19 | 0.41 | 0.22 | 0.26 | 0.91 | 0.41 | 0.14 | 0.52 | 0.29 | 0.60 | 0.55 | 0.75 | 0.60 | 0.36 | 0.05 | 0.23 | 
|---|
|
| 218G 1.00 | 0.12 | 0.07 | 0.13 | 0.03 | 0.00 | 1.00 | 0.02 | 0.00 | 0.03 | 0.01 | 0.00 | 0.23 | 0.02 | 0.02 | 0.01 | 0.24 | 0.02 | 0.01 | 0.00 | 0.01 | 
|---|
|
| 219D 1.00 | 0.75 | 0.05 | 0.68 | 1.00 | 0.05 | 0.41 | 0.12 | 0.19 | 0.90 | 0.32 | 0.10 | 0.50 | 0.26 | 0.59 | 0.50 | 0.72 | 0.55 | 0.27 | 0.02 | 0.04 | 
|---|
|
| 220W 1.00 | 0.34 | 0.12 | 0.14 | 0.21 | 0.67 | 0.25 | 0.37 | 0.30 | 0.23 | 0.44 | 0.15 | 0.21 | 0.22 | 0.20 | 0.23 | 0.27 | 0.26 | 0.34 | 0.24 | 1.00 | 
|---|
|
| 221S 1.00 | 0.71 | 0.06 | 0.78 | 0.93 | 0.10 | 0.44 | 0.14 | 0.18 | 0.94 | 0.29 | 0.10 | 0.56 | 0.26 | 0.55 | 0.51 | 1.00 | 0.86 | 0.27 | 0.02 | 0.07 | 
|---|
|
| 222A 1.00 | 0.51 | 0.17 | 0.20 | 0.27 | 0.69 | 0.32 | 0.52 | 0.38 | 0.28 | 0.64 | 0.22 | 0.30 | 0.21 | 0.28 | 0.34 | 0.39 | 0.38 | 0.51 | 0.18 | 1.00 | 
|---|
|
| 223M 1.00 | 0.44 | 0.03 | 0.63 | 1.00 | 0.03 | 0.22 | 0.07 | 0.11 | 0.67 | 0.17 | 0.27 | 0.33 | 0.16 | 0.48 | 0.41 | 0.61 | 0.33 | 0.16 | 0.01 | 0.02 | 
|---|
|
| 224S 1.00 | 0.43 | 0.03 | 0.47 | 0.63 | 0.03 | 0.51 | 0.13 | 0.08 | 0.41 | 0.13 | 0.05 | 0.29 | 0.13 | 0.33 | 0.22 | 1.00 | 0.25 | 0.12 | 0.01 | 0.03 | 
|---|
|
| 225G 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 226F 1.00 | 0.35 | 0.12 | 0.14 | 0.29 | 0.65 | 0.23 | 0.41 | 0.31 | 0.24 | 0.52 | 0.19 | 0.21 | 0.14 | 0.26 | 0.24 | 0.28 | 0.27 | 0.37 | 0.13 | 1.00 | 
|---|
|
| 227Q 1.00 | 0.85 | 0.04 | 0.41 | 1.00 | 0.03 | 0.25 | 0.14 | 0.12 | 0.76 | 0.20 | 0.07 | 0.42 | 0.18 | 0.78 | 0.47 | 0.51 | 0.38 | 0.19 | 0.01 | 0.03 | 
|---|
|
| 228Q 1.00 | 1.00 | 0.10 | 0.11 | 0.16 | 0.12 | 0.49 | 0.07 | 0.15 | 0.18 | 0.43 | 0.11 | 0.10 | 0.23 | 0.15 | 0.14 | 0.47 | 0.21 | 0.23 | 0.03 | 0.10 | 
|---|
|
| 229T 1.00 | 0.93 | 0.17 | 0.19 | 0.25 | 0.76 | 0.31 | 0.50 | 0.45 | 0.27 | 0.77 | 0.81 | 0.29 | 0.19 | 0.27 | 0.32 | 0.37 | 0.62 | 0.61 | 0.22 | 1.00 | 
|---|
|
| 230M 1.00 | 0.71 | 0.05 | 0.60 | 1.00 | 0.05 | 0.35 | 0.11 | 0.18 | 0.91 | 0.28 | 0.14 | 0.46 | 0.27 | 0.57 | 0.49 | 0.71 | 0.56 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 231Q 1.00 | 0.58 | 0.03 | 0.44 | 1.00 | 0.03 | 0.21 | 0.22 | 0.10 | 0.75 | 0.17 | 0.06 | 0.27 | 0.15 | 0.94 | 0.88 | 0.73 | 0.32 | 0.16 | 0.01 | 0.02 | 
|---|
|
| 232M 1.00 | 0.19 | 0.02 | 0.02 | 0.03 | 0.15 | 0.04 | 0.06 | 0.08 | 0.10 | 1.00 | 0.33 | 0.03 | 0.02 | 0.03 | 0.04 | 0.04 | 0.05 | 0.15 | 0.02 | 0.17 | 
|---|
|
| 233L 1.00 | 0.14 | 0.01 | 0.02 | 0.03 | 0.06 | 0.02 | 0.03 | 0.37 | 0.03 | 1.00 | 0.08 | 0.02 | 0.02 | 0.06 | 0.06 | 0.06 | 0.04 | 0.08 | 0.01 | 0.05 | 
|---|
|
| 234N 0.93 | 0.79 | 0.05 | 0.63 | 1.00 | 0.06 | 0.41 | 0.12 | 0.18 | 0.95 | 0.30 | 0.10 | 0.55 | 0.27 | 0.57 | 0.51 | 0.73 | 0.58 | 0.28 | 0.02 | 0.05 | 
|---|
|
| 235E 0.93 | 0.82 | 0.13 | 0.56 | 1.00 | 0.39 | 0.44 | 0.36 | 0.33 | 0.90 | 0.63 | 0.19 | 0.52 | 0.30 | 0.60 | 0.69 | 0.81 | 0.61 | 0.47 | 0.11 | 0.55 | 
|---|
|
| 236G 0.96 | 0.33 | 0.05 | 0.39 | 0.46 | 0.12 | 1.00 | 0.26 | 0.12 | 0.36 | 0.20 | 0.07 | 0.38 | 0.20 | 0.24 | 0.27 | 0.35 | 0.25 | 0.17 | 0.03 | 0.16 | 
|---|
|
| 237I 0.71 | 0.81 | 0.20 | 0.46 | 0.68 | 0.71 | 0.48 | 0.58 | 0.47 | 0.67 | 0.76 | 0.26 | 0.51 | 0.32 | 0.53 | 0.56 | 0.69 | 0.62 | 0.61 | 0.19 | 1.00 | 
|---|
|
| 238V 0.75 | 0.63 | 0.18 | 0.31 | 0.44 | 0.71 | 0.39 | 0.56 | 0.42 | 0.45 | 0.70 | 0.24 | 0.39 | 0.25 | 0.39 | 0.43 | 0.52 | 0.48 | 0.55 | 0.19 | 1.00 | 
|---|
|
| 239P 1.00 | 0.50 | 0.11 | 0.05 | 0.10 | 0.16 | 0.05 | 0.10 | 0.49 | 0.11 | 0.41 | 0.12 | 0.08 | 0.15 | 0.09 | 0.09 | 0.12 | 0.36 | 1.00 | 0.04 | 0.17 | 
|---|
|
| 240T 1.00 | 0.20 | 0.02 | 0.59 | 0.44 | 0.02 | 0.25 | 0.14 | 0.04 | 0.36 | 0.07 | 0.02 | 0.48 | 0.10 | 0.18 | 0.14 | 0.28 | 1.00 | 0.06 | 0.01 | 0.04 | 
|---|
|
| 241A 1.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.08 | 0.01 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 242M 1.00 | 0.26 | 0.02 | 0.01 | 0.02 | 0.21 | 0.02 | 0.03 | 0.66 | 0.02 | 0.32 | 0.27 | 0.02 | 0.02 | 0.02 | 0.02 | 0.03 | 0.05 | 1.00 | 0.01 | 0.13 | 
|---|
|
| 243L 1.00 | 0.14 | 0.03 | 0.02 | 0.03 | 0.66 | 0.04 | 0.04 | 0.84 | 0.04 | 0.75 | 0.10 | 0.03 | 0.03 | 0.03 | 0.04 | 0.04 | 0.07 | 1.00 | 0.02 | 0.14 | 
|---|
|
| 244V 1.00 | 0.50 | 0.27 | 0.02 | 0.05 | 0.03 | 0.01 | 0.01 | 0.37 | 0.05 | 0.20 | 0.06 | 0.02 | 0.07 | 0.03 | 0.03 | 0.11 | 0.27 | 1.00 | 0.01 | 0.01 | 
|---|
|
| 245A 1.00 | 1.00 | 0.06 | 0.08 | 0.09 | 0.15 | 0.29 | 0.12 | 0.18 | 0.10 | 0.16 | 0.06 | 0.10 | 0.10 | 0.09 | 0.10 | 0.38 | 0.30 | 0.15 | 0.04 | 0.34 | 
|---|
|
| 246N 1.00 | 0.06 | 0.01 | 0.26 | 0.14 | 0.01 | 0.08 | 0.11 | 0.01 | 0.15 | 0.02 | 0.01 | 1.00 | 0.03 | 0.05 | 0.04 | 0.77 | 0.15 | 0.02 | 0.00 | 0.01 | 
|---|
|
| 247D 1.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 248Q 1.00 | 0.73 | 0.05 | 0.62 | 1.00 | 0.05 | 0.37 | 0.12 | 0.18 | 0.89 | 0.31 | 0.11 | 0.48 | 0.26 | 0.59 | 0.51 | 0.74 | 0.57 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 249M 1.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.05 | 0.01 | 0.01 | 0.24 | 0.01 | 0.48 | 1.00 | 0.01 | 0.01 | 0.06 | 0.01 | 0.13 | 0.02 | 0.16 | 0.01 | 0.01 | 
|---|
|
| 250A 1.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 251L 1.00 | 0.26 | 0.02 | 0.01 | 0.02 | 0.17 | 0.02 | 0.02 | 0.65 | 0.03 | 1.00 | 0.19 | 0.02 | 0.03 | 0.09 | 0.02 | 0.03 | 0.07 | 0.52 | 0.02 | 0.04 | 
|---|
|
| 252G 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 253A 1.00 | 1.00 | 0.05 | 0.01 | 0.04 | 0.08 | 0.01 | 0.01 | 0.48 | 0.04 | 0.65 | 0.11 | 0.02 | 0.06 | 0.04 | 0.03 | 0.04 | 0.19 | 0.75 | 0.01 | 0.02 | 
|---|
|
| 254M 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.51 | 0.00 | 1.00 | 0.45 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.22 | 0.00 | 0.00 | 
|---|
|
| 255R 1.00 | 0.43 | 0.03 | 0.45 | 0.57 | 0.03 | 0.30 | 0.26 | 0.11 | 0.68 | 0.17 | 0.06 | 0.61 | 0.16 | 0.42 | 1.00 | 0.56 | 0.39 | 0.16 | 0.01 | 0.03 | 
|---|
|
| 256A 1.00 | 1.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.16 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.01 | 0.17 | 0.00 | 0.00 | 
|---|
|
| 257I 1.00 | 0.32 | 0.01 | 0.01 | 0.01 | 0.11 | 0.01 | 0.01 | 0.45 | 0.02 | 1.00 | 0.20 | 0.01 | 0.02 | 0.02 | 0.02 | 0.01 | 0.04 | 0.16 | 0.01 | 0.02 | 
|---|
|
| 258T 1.00 | 0.60 | 0.18 | 0.28 | 0.40 | 0.72 | 0.37 | 0.57 | 0.42 | 0.42 | 0.71 | 0.24 | 0.39 | 0.24 | 0.40 | 0.46 | 0.49 | 0.49 | 0.53 | 0.19 | 1.00 | 
|---|
|
| 259E 1.00 | 0.20 | 0.00 | 1.00 | 0.97 | 0.01 | 0.02 | 0.01 | 0.01 | 0.06 | 0.01 | 0.01 | 0.02 | 0.04 | 0.27 | 0.02 | 0.03 | 0.03 | 0.01 | 0.00 | 0.01 | 
|---|
|
| 260S 1.00 | 0.77 | 0.06 | 0.62 | 1.00 | 0.09 | 0.39 | 0.15 | 0.20 | 0.96 | 0.34 | 0.12 | 0.51 | 0.28 | 0.60 | 0.56 | 0.74 | 0.58 | 0.31 | 0.03 | 0.09 | 
|---|
|
| 261G 1.00 | 0.01 | 0.00 | 0.04 | 0.04 | 0.00 | 1.00 | 0.01 | 0.00 | 0.07 | 0.00 | 0.00 | 0.19 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 262L 1.00 | 0.13 | 0.02 | 0.01 | 0.02 | 0.07 | 0.01 | 0.01 | 0.73 | 0.02 | 1.00 | 0.13 | 0.01 | 0.02 | 0.02 | 0.16 | 0.02 | 0.06 | 0.65 | 0.01 | 0.02 | 
|---|
|
| 263R 1.00 | 0.63 | 0.04 | 0.65 | 0.88 | 0.04 | 0.29 | 0.09 | 0.14 | 1.00 | 0.28 | 0.08 | 0.51 | 0.21 | 0.51 | 0.70 | 0.64 | 0.50 | 0.22 | 0.01 | 0.03 | 
|---|
|
| 264V 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.16 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 265G 1.00 | 0.11 | 0.01 | 0.02 | 0.02 | 0.01 | 0.23 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.02 | 1.00 | 0.01 | 0.02 | 0.06 | 0.02 | 0.02 | 0.00 | 0.01 | 
|---|
|
| 266A 1.00 | 0.75 | 0.05 | 0.65 | 1.00 | 0.04 | 0.39 | 0.11 | 0.17 | 0.88 | 0.29 | 0.09 | 0.49 | 0.24 | 0.61 | 0.49 | 0.67 | 0.51 | 0.25 | 0.02 | 0.03 | 
|---|
|
| 267D 1.00 | 0.02 | 0.00 | 1.00 | 0.26 | 0.00 | 0.01 | 0.05 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 | 0.07 | 0.07 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 268I 1.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.42 | 0.01 | 0.00 | 1.00 | 0.01 | 0.60 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.11 | 0.80 | 0.00 | 0.01 | 
|---|
|
| 269S 1.00 | 0.20 | 0.00 | 0.16 | 0.55 | 0.00 | 0.03 | 0.01 | 0.01 | 0.06 | 0.02 | 0.01 | 0.03 | 0.03 | 0.18 | 0.02 | 1.00 | 0.03 | 0.02 | 0.00 | 0.01 | 
|---|
|
| 270V 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.78 | 0.00 | 0.20 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 271V 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 1.00 | 0.00 | 0.04 | 0.12 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.79 | 0.00 | 0.00 | 
|---|
|
| 272G 1.00 | 0.09 | 0.01 | 0.03 | 0.02 | 0.01 | 1.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 | 0.03 | 0.03 | 0.01 | 0.01 | 0.50 | 0.31 | 0.02 | 0.00 | 0.01 | 
|---|
|
| 273Y 1.00 | 0.19 | 0.04 | 0.05 | 0.07 | 1.00 | 0.15 | 0.13 | 0.09 | 0.07 | 0.15 | 0.05 | 0.07 | 0.05 | 0.07 | 0.08 | 0.24 | 0.09 | 0.19 | 0.04 | 0.50 | 
|---|
|
| 274D 1.00 | 0.10 | 0.00 | 1.00 | 0.10 | 0.00 | 0.07 | 0.02 | 0.00 | 0.03 | 0.01 | 0.00 | 0.68 | 0.02 | 0.03 | 0.02 | 0.12 | 0.02 | 0.01 | 0.00 | 0.01 | 
|---|
|
| 275D 1.00 | 0.07 | 0.00 | 1.00 | 0.02 | 0.00 | 0.11 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.38 | 0.01 | 0.01 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.01 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 276T 1.00 | 0.18 | 0.03 | 0.15 | 0.10 | 0.03 | 0.06 | 0.04 | 0.33 | 0.11 | 0.08 | 0.08 | 0.17 | 0.08 | 0.08 | 0.07 | 0.74 | 1.00 | 0.23 | 0.01 | 0.04 | 
|---|
|
| 277E 1.00 | 0.70 | 0.05 | 0.55 | 1.00 | 0.07 | 0.37 | 0.11 | 0.17 | 0.85 | 0.31 | 0.09 | 0.44 | 0.46 | 0.54 | 0.51 | 0.68 | 0.55 | 0.25 | 0.02 | 0.04 | 
|---|
|
| 278D 1.00 | 0.51 | 0.13 | 0.21 | 0.24 | 0.38 | 0.17 | 0.25 | 0.74 | 0.22 | 0.72 | 0.17 | 0.18 | 0.16 | 0.19 | 0.21 | 0.26 | 0.40 | 1.00 | 0.09 | 0.46 | 
|---|
|
| 279S 1.00 | 1.00 | 0.03 | 0.02 | 0.03 | 0.02 | 0.03 | 0.01 | 0.32 | 0.04 | 0.08 | 0.03 | 0.04 | 0.05 | 0.03 | 0.02 | 0.78 | 0.48 | 0.30 | 0.00 | 0.01 | 
|---|
|
| 280S 1.00 | 0.76 | 0.05 | 0.59 | 1.00 | 0.05 | 0.36 | 0.12 | 0.18 | 0.92 | 0.32 | 0.10 | 0.47 | 0.26 | 0.59 | 0.56 | 0.80 | 0.55 | 0.29 | 0.02 | 0.04 | 
|---|
|
| 281C 1.00 | 0.42 | 0.23 | 0.17 | 0.23 | 0.73 | 0.27 | 0.45 | 0.35 | 0.24 | 0.55 | 0.26 | 0.26 | 0.17 | 0.29 | 0.29 | 0.33 | 0.36 | 0.46 | 0.15 | 1.00 | 
|---|
|
| 282Y 1.00 | 0.51 | 0.19 | 0.19 | 0.26 | 0.68 | 0.31 | 0.51 | 0.42 | 0.28 | 0.64 | 0.21 | 0.29 | 0.20 | 0.28 | 0.33 | 0.40 | 0.53 | 0.61 | 0.17 | 1.00 | 
|---|
|
| 283I 1.00 | 0.52 | 0.18 | 0.21 | 0.28 | 0.70 | 0.33 | 0.54 | 0.40 | 0.30 | 0.65 | 0.22 | 0.31 | 0.21 | 0.30 | 0.36 | 0.42 | 0.41 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 284P 1.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 285P 1.00 | 0.57 | 0.04 | 0.39 | 0.68 | 0.05 | 0.27 | 0.12 | 0.14 | 1.00 | 0.28 | 0.08 | 0.39 | 0.92 | 0.72 | 0.84 | 0.49 | 0.47 | 0.20 | 0.02 | 0.05 | 
|---|
|
| 286L 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.09 | 0.00 | 1.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.00 | 0.10 | 0.01 | 0.03 | 0.00 | 0.00 | 
|---|
|
| 287T 1.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.49 | 1.00 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 288T 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.29 | 1.00 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 289I 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.49 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 290K 1.00 | 0.55 | 0.04 | 0.48 | 0.72 | 0.05 | 0.31 | 0.15 | 0.18 | 1.00 | 0.23 | 0.08 | 0.41 | 0.20 | 0.43 | 0.82 | 0.61 | 0.50 | 0.30 | 0.02 | 0.05 | 
|---|
|
| 291Q 1.00 | 0.66 | 0.17 | 0.26 | 0.46 | 0.64 | 0.38 | 0.56 | 0.45 | 0.98 | 0.69 | 0.23 | 0.40 | 0.28 | 0.95 | 0.89 | 0.50 | 0.50 | 0.64 | 0.18 | 1.00 | 
|---|
|
| 292D 1.00 | 0.25 | 0.04 | 0.57 | 0.30 | 0.12 | 0.26 | 0.21 | 0.07 | 0.16 | 0.12 | 0.04 | 0.37 | 1.00 | 0.14 | 0.11 | 0.24 | 0.14 | 0.10 | 0.04 | 0.30 | 
|---|
|
| 293F 1.00 | 0.40 | 0.13 | 0.13 | 0.18 | 0.49 | 0.21 | 0.32 | 0.91 | 0.20 | 0.83 | 0.22 | 0.19 | 0.14 | 0.19 | 0.22 | 0.26 | 0.32 | 1.00 | 0.12 | 0.60 | 
|---|
|
| 294R 1.00 | 0.64 | 0.08 | 0.59 | 1.00 | 0.21 | 0.33 | 0.22 | 0.22 | 0.70 | 0.36 | 0.12 | 0.40 | 0.25 | 0.51 | 0.42 | 0.57 | 0.47 | 0.31 | 0.06 | 0.28 | 
|---|
|
| 295L 1.00 | 0.74 | 0.05 | 0.66 | 1.00 | 0.05 | 0.36 | 0.12 | 0.18 | 0.90 | 0.32 | 0.11 | 0.47 | 0.26 | 0.57 | 0.50 | 0.71 | 0.56 | 0.27 | 0.02 | 0.04 | 
|---|
|
| 296L 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.47 | 0.00 | 0.60 | 1.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 
|---|
|
| 297G 1.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.01 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 298Q 1.00 | 1.00 | 0.05 | 0.60 | 0.96 | 0.06 | 0.37 | 0.13 | 0.19 | 0.94 | 0.34 | 0.10 | 0.48 | 0.27 | 0.77 | 0.63 | 0.77 | 0.62 | 0.32 | 0.02 | 0.05 | 
|---|
|
| 299T 1.00 | 0.45 | 0.08 | 0.06 | 0.09 | 0.16 | 0.07 | 0.12 | 0.29 | 0.10 | 0.39 | 0.09 | 0.08 | 0.09 | 0.20 | 0.09 | 0.13 | 0.64 | 1.00 | 0.04 | 0.25 | 
|---|
|
| 300S 1.00 | 1.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.31 | 0.00 | 0.00 | 0.01 | 0.01 | 0.07 | 0.01 | 0.03 | 0.01 | 0.01 | 0.29 | 0.02 | 0.02 | 0.00 | 0.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 301V 1.00 | 0.45 | 0.04 | 0.01 | 0.03 | 0.09 | 0.01 | 0.01 | 0.22 | 0.03 | 0.17 | 0.58 | 0.02 | 0.04 | 0.02 | 0.02 | 0.03 | 0.20 | 1.00 | 0.01 | 0.01 | 
|---|
|
| 302D 1.00 | 0.22 | 0.01 | 0.57 | 0.71 | 0.02 | 0.12 | 0.05 | 0.05 | 0.44 | 0.08 | 0.03 | 0.24 | 0.09 | 0.28 | 1.00 | 0.20 | 0.16 | 0.08 | 0.01 | 0.02 | 
|---|
|
| 303R 1.00 | 0.28 | 0.05 | 0.08 | 0.15 | 0.14 | 0.08 | 0.09 | 0.33 | 0.29 | 1.00 | 0.22 | 0.10 | 0.08 | 0.13 | 0.34 | 0.13 | 0.25 | 0.32 | 0.03 | 0.13 | 
|---|
|
| 304L 1.00 | 0.15 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.04 | 0.00 | 1.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.10 | 0.00 | 0.00 | 
|---|
|
| 305L 1.00 | 0.49 | 0.20 | 0.24 | 0.27 | 0.66 | 0.32 | 0.51 | 0.40 | 0.29 | 0.88 | 0.21 | 0.33 | 0.20 | 0.32 | 0.34 | 0.40 | 0.57 | 0.48 | 0.17 | 1.00 | 
|---|
|
| 306Q 1.00 | 0.50 | 0.02 | 0.61 | 0.91 | 0.02 | 0.17 | 0.06 | 0.08 | 1.00 | 0.13 | 0.05 | 0.21 | 0.13 | 0.70 | 0.22 | 0.47 | 0.24 | 0.12 | 0.01 | 0.02 | 
|---|
|
| 307L 1.00 | 0.52 | 0.17 | 0.21 | 0.32 | 0.69 | 0.34 | 0.55 | 0.40 | 0.34 | 0.76 | 0.22 | 0.31 | 0.21 | 0.31 | 0.40 | 0.41 | 0.40 | 0.50 | 0.18 | 1.00 | 
|---|
|
| 308S 1.00 | 0.59 | 0.09 | 0.05 | 0.09 | 0.17 | 0.05 | 0.05 | 0.90 | 0.10 | 1.00 | 0.56 | 0.07 | 0.11 | 0.08 | 0.07 | 0.34 | 0.41 | 0.90 | 0.03 | 0.08 | 
|---|
|
| 309Q 1.00 | 0.82 | 0.05 | 0.78 | 0.91 | 0.05 | 0.45 | 0.11 | 0.17 | 1.00 | 0.35 | 0.10 | 0.94 | 0.25 | 0.77 | 0.47 | 0.89 | 0.56 | 0.26 | 0.02 | 0.03 | 
|---|
|
| 310G 1.00 | 0.35 | 0.03 | 0.61 | 0.75 | 0.03 | 1.00 | 0.09 | 0.08 | 0.73 | 0.13 | 0.05 | 0.50 | 0.22 | 0.29 | 0.24 | 0.44 | 0.27 | 0.12 | 0.01 | 0.04 | 
|---|
|
| 311Q 1.00 | 0.33 | 0.02 | 0.27 | 1.00 | 0.02 | 0.17 | 0.15 | 0.08 | 0.80 | 0.14 | 0.05 | 0.29 | 0.22 | 0.55 | 0.74 | 0.32 | 0.38 | 0.13 | 0.01 | 0.02 | 
|---|
|
| 312A 1.00 | 0.76 | 0.05 | 0.62 | 1.00 | 0.05 | 0.38 | 0.12 | 0.19 | 0.91 | 0.29 | 0.10 | 0.48 | 0.28 | 0.57 | 0.51 | 0.72 | 0.56 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 313V 1.00 | 0.35 | 0.06 | 0.02 | 0.10 | 0.03 | 0.00 | 0.01 | 0.53 | 0.04 | 0.47 | 0.06 | 0.02 | 0.15 | 0.03 | 0.03 | 0.04 | 0.26 | 1.00 | 0.01 | 0.01 | 
|---|
|
| 314K 1.00 | 0.35 | 0.01 | 0.32 | 1.00 | 0.02 | 0.10 | 0.04 | 0.04 | 0.57 | 0.07 | 0.03 | 0.12 | 0.70 | 0.20 | 0.19 | 0.17 | 0.14 | 0.07 | 0.01 | 0.02 | 
|---|
|
| 315G 1.00 | 0.75 | 0.05 | 0.62 | 1.00 | 0.05 | 0.38 | 0.12 | 0.19 | 0.92 | 0.30 | 0.10 | 0.49 | 0.28 | 0.59 | 0.53 | 0.73 | 0.57 | 0.28 | 0.02 | 0.04 | 
|---|
|
| 316N 1.00 | 0.74 | 0.06 | 0.61 | 1.00 | 0.06 | 0.38 | 0.16 | 0.20 | 0.93 | 0.34 | 0.11 | 0.57 | 0.27 | 0.60 | 0.53 | 0.78 | 0.59 | 0.30 | 0.02 | 0.06 | 
|---|
|
| 317Q 1.00 | 0.55 | 0.17 | 0.25 | 0.38 | 0.68 | 0.35 | 0.55 | 0.45 | 0.41 | 0.65 | 0.22 | 0.34 | 0.22 | 0.42 | 0.40 | 0.45 | 0.47 | 0.69 | 0.18 | 1.00 | 
|---|
|
| 318L 1.00 | 0.31 | 0.18 | 0.13 | 0.17 | 0.53 | 0.20 | 0.34 | 0.52 | 0.26 | 0.66 | 0.27 | 0.28 | 0.13 | 0.25 | 0.22 | 0.25 | 0.32 | 1.00 | 0.11 | 0.67 | 
|---|
|
| 319L 1.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 | 0.07 | 0.00 | 1.00 | 0.04 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.10 | 0.01 | 0.01 | 
|---|
|
| 320P 1.00 | 0.62 | 0.04 | 0.66 | 1.00 | 0.04 | 0.41 | 0.11 | 0.15 | 0.81 | 0.25 | 0.19 | 0.51 | 0.74 | 0.49 | 0.43 | 0.66 | 0.47 | 0.23 | 0.02 | 0.04 | 
|---|
|
| 321V 1.00 | 0.50 | 0.18 | 0.20 | 0.27 | 0.70 | 0.33 | 0.55 | 0.39 | 0.29 | 0.65 | 0.22 | 0.31 | 0.22 | 0.29 | 0.35 | 0.41 | 0.40 | 0.51 | 0.18 | 1.00 | 
|---|
|
| 322S 1.00 | 0.41 | 0.03 | 0.36 | 1.00 | 0.03 | 0.26 | 0.10 | 0.10 | 0.60 | 0.16 | 0.06 | 0.27 | 0.15 | 0.32 | 0.37 | 0.58 | 0.48 | 0.15 | 0.01 | 0.02 | 
|---|
|
| 323L 1.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.09 | 0.00 | 0.00 | 0.39 | 0.00 | 1.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.04 | 0.00 | 0.00 | 
|---|
|
| 324V 1.00 | 0.52 | 0.08 | 0.38 | 0.66 | 0.28 | 0.28 | 0.23 | 0.51 | 0.66 | 0.39 | 0.20 | 0.32 | 0.19 | 0.40 | 0.35 | 0.46 | 0.46 | 1.00 | 0.07 | 0.34 | 
|---|
|
| 325K 1.00 | 0.63 | 0.18 | 0.31 | 0.45 | 0.71 | 0.39 | 0.56 | 0.42 | 0.48 | 0.71 | 0.24 | 0.39 | 0.25 | 0.40 | 0.45 | 0.52 | 0.48 | 0.57 | 0.19 | 1.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 326R 1.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 327K 1.00 | 0.73 | 0.05 | 0.61 | 1.00 | 0.07 | 0.47 | 0.15 | 0.18 | 0.93 | 0.29 | 0.10 | 0.48 | 0.26 | 0.59 | 0.51 | 0.69 | 0.54 | 0.27 | 0.02 | 0.04 | 
|---|
|
| 328T 1.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 1.00 | 0.41 | 0.01 | 0.00 | 0.00 | 
|---|
|
| 329T 0.93 | 0.03 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.13 | 1.00 | 0.30 | 0.00 | 0.00 | 
|---|
|
| 330L 0.86 | 0.57 | 0.05 | 0.36 | 0.65 | 0.06 | 0.31 | 0.14 | 0.14 | 1.00 | 0.28 | 0.09 | 0.35 | 0.22 | 0.48 | 0.69 | 0.50 | 0.40 | 0.22 | 0.03 | 0.08 | 
|---|
|
| 331A 0.39 | 1.00 | 0.05 | 0.57 | 0.98 | 0.05 | 0.35 | 0.12 | 0.17 | 0.85 | 0.28 | 0.10 | 0.45 | 0.25 | 0.63 | 0.59 | 0.86 | 0.62 | 0.37 | 0.02 | 0.04 | 
|---|
|
| 332P 0.32 | 1.00 | 0.21 | 0.35 | 0.52 | 0.64 | 0.51 | 0.50 | 0.57 | 0.60 | 0.99 | 0.29 | 0.40 | 0.39 | 0.44 | 0.53 | 0.65 | 0.60 | 0.81 | 0.16 | 0.83 | 
|---|
|
| 333N 0.29 | 0.65 | 0.07 | 0.54 | 0.72 | 0.07 | 0.35 | 0.13 | 0.17 | 0.73 | 0.26 | 0.10 | 0.66 | 0.32 | 0.46 | 0.48 | 0.98 | 1.00 | 0.26 | 0.03 | 0.08 | 
|---|
|
| 334T 0.25 | 1.00 | 0.10 | 0.16 | 0.17 | 0.05 | 0.59 | 0.04 | 0.07 | 0.18 | 0.12 | 0.05 | 0.17 | 0.25 | 0.12 | 0.12 | 0.66 | 0.72 | 0.18 | 0.02 | 0.05 | 
|---|
|
| 335Q 0.21 | 0.18 | 0.01 | 0.25 | 0.81 | 0.02 | 0.10 | 0.04 | 0.04 | 0.22 | 0.07 | 0.02 | 0.12 | 0.08 | 1.00 | 0.12 | 0.44 | 0.13 | 0.06 | 0.01 | 0.02 | 
|---|
|
| 336T 0.21 | 0.56 | 0.09 | 0.26 | 0.48 | 0.20 | 0.26 | 0.22 | 0.33 | 1.00 | 0.55 | 0.16 | 0.34 | 0.24 | 0.46 | 0.80 | 0.60 | 0.73 | 0.46 | 0.06 | 0.23 | 
|---|
|
| 337A 0.21 | 1.00 | 0.03 | 0.04 | 0.04 | 0.01 | 0.70 | 0.01 | 0.01 | 0.04 | 0.03 | 0.01 | 0.03 | 0.08 | 0.03 | 0.03 | 0.16 | 0.06 | 0.05 | 0.00 | 0.01 | 
|---|
|
| 338S 0.21 | 0.59 | 0.05 | 0.52 | 0.95 | 0.06 | 0.34 | 0.14 | 0.15 | 0.87 | 0.25 | 0.09 | 0.43 | 0.24 | 0.49 | 0.74 | 1.00 | 0.48 | 0.22 | 0.02 | 0.08 | 
|---|
|
| 339P 0.21 | 0.14 | 0.01 | 0.11 | 0.18 | 0.02 | 0.09 | 0.03 | 0.03 | 0.15 | 0.05 | 0.02 | 0.07 | 1.00 | 0.30 | 0.10 | 0.10 | 0.08 | 0.05 | 0.01 | 0.02 | 
|---|
|
| 340R 0.14 | 0.52 | 0.08 | 0.15 | 0.36 | 0.15 | 0.23 | 0.18 | 0.46 | 0.99 | 0.50 | 0.14 | 0.24 | 0.21 | 0.41 | 1.00 | 0.33 | 0.40 | 0.71 | 0.05 | 0.18 | 
|---|
|
| 341A 0.14 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 342L 0.14 | 0.22 | 0.04 | 0.05 | 0.08 | 0.19 | 0.09 | 0.04 | 0.36 | 0.10 | 1.00 | 0.21 | 0.06 | 0.10 | 0.08 | 0.09 | 0.11 | 0.13 | 0.30 | 0.03 | 0.07 | 
|---|
|
| 343A 0.14 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 344D 0.11 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 345S 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 346L 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 347M 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 348Q 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 349L 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 350A 0.11 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
| pos | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y | 
|---|
| 351R 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 352Q 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 353V 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 
|---|
|
| 354S 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 355R 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 356L 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 357E 0.11 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 358S 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 359G 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|
|
| 360Q 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 
|---|